Iron distribution and histopathological characterization of the liver and heart of β-thalassemic mice with parenteral iron overload: Effects of deferoxamine and deferiprone

• Main Authors: Paranee Yatmark, Noppawan Phumala Morales, Urai Chaisri, Surasak Wichaiyo, Warinkarn Hemstapat, Somdet Srichairatanakool, Saovaros Svasti, Suthat Fucharoen
• Format: Journal
• Published: 2018
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84902819565&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/45448
• Institution: Chiang Mai University

The liver and heart are the major target organs for iron accumulation and iron toxicity in β-thalassemia. To mimic the phenomenon of heavy iron overload resulting from repeated blood transfusions, a total of 180mg of iron dextran was intraperitoneally injected into C57BL/6J mice (WT) and heterozygou...