An optimized expression vector for improving the yield of dengue virus-like particles from transfected insect cells

• Main Authors: Charoensri N., Suphatrakul A., Sriburi R., Yasanga T., Junjhon J., Keelapang P., Utaipat U., Puttikhunt C., Kasinrerk W., Malasit P., Sittisombut N.
• Format: Article
• Language: English
• Published: Elsevier 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84902001370&partnerID=40&md5=1cd1e3045a0423ee62f7562b3ddf6966; http://cmuir.cmu.ac.th/handle/6653943832/1752
• Institution: Chiang Mai University

Recombinant virus-like particles (rVLPs) of flaviviruses are non-infectious particles released from cells expressing the envelope glycoproteins prM and E. Dengue virus rVLPs are recognized as a potential vaccine candidate, but large scale production of these particles is hindered by low yields and t...