Anticoagulant activity of a sulfated chitosan.
Chitin prepared from the shells of rice-field crabs (Somanniathelphusa dugasti) was converted into chitosan with a degree of acetylation of 0.21 and then sulfated with chlorosulfonic acid in N,N-dimethylformamide under semi-heterogeneous conditions to give 87% of water-soluble sulfated chitosan with...
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2014
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th-cmuir.6653943832-25122014-08-30T02:00:55Z Anticoagulant activity of a sulfated chitosan. Vongchan P. Sajomsang W. Subyen D. Kongtawelert P. Chitin prepared from the shells of rice-field crabs (Somanniathelphusa dugasti) was converted into chitosan with a degree of acetylation of 0.21 and then sulfated with chlorosulfonic acid in N,N-dimethylformamide under semi-heterogeneous conditions to give 87% of water-soluble sulfated chitosan with degree of substitution (d.s) of 2.13. 1H NMR revealed the sulfate substitution at C-2, C-3 and C-6. Gel filtration on Sepharose CL-6B of the sulfated chitosan gave three fractions with average molecular weights of 7.1, 3.5, and 1.9 x 10(4). The three sulfated chitosan preparations showed strong anticoagulant activities, with the same mechanism of action observed for standard therapeutic heparin. 2014-08-30T02:00:55Z 2014-08-30T02:00:55Z 2002 Article 00086215 12110200 http://www.scopus.com/inward/record.url?eid=2-s2.0-1842834328&partnerID=40&md5=d1629802eb3fadb845af79f7e1b8b61e http://cmuir.cmu.ac.th/handle/6653943832/2512 English |
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Chitin prepared from the shells of rice-field crabs (Somanniathelphusa dugasti) was converted into chitosan with a degree of acetylation of 0.21 and then sulfated with chlorosulfonic acid in N,N-dimethylformamide under semi-heterogeneous conditions to give 87% of water-soluble sulfated chitosan with degree of substitution (d.s) of 2.13. 1H NMR revealed the sulfate substitution at C-2, C-3 and C-6. Gel filtration on Sepharose CL-6B of the sulfated chitosan gave three fractions with average molecular weights of 7.1, 3.5, and 1.9 x 10(4). The three sulfated chitosan preparations showed strong anticoagulant activities, with the same mechanism of action observed for standard therapeutic heparin. |
| format |
Article |
| author |
Vongchan P. Sajomsang W. Subyen D. Kongtawelert P. |
| spellingShingle |
Vongchan P. Sajomsang W. Subyen D. Kongtawelert P. Anticoagulant activity of a sulfated chitosan. |
| author_facet |
Vongchan P. Sajomsang W. Subyen D. Kongtawelert P. |
| author_sort |
Vongchan P. |
| title |
Anticoagulant activity of a sulfated chitosan. |
| title_short |
Anticoagulant activity of a sulfated chitosan. |
| title_full |
Anticoagulant activity of a sulfated chitosan. |
| title_fullStr |
Anticoagulant activity of a sulfated chitosan. |
| title_full_unstemmed |
Anticoagulant activity of a sulfated chitosan. |
| title_sort |
anticoagulant activity of a sulfated chitosan. |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-1842834328&partnerID=40&md5=d1629802eb3fadb845af79f7e1b8b61e http://cmuir.cmu.ac.th/handle/6653943832/2512 |
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1681419872739786752 |