Down-regulation of the human VEGF gene expression by perylene monoimide derivatives

• Main Authors: Taka T., Joonlasak K., Huang L., Randall Lee T., Chang S.-W.T., Tuntiwechapikul W.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-81155131331&partnerID=40&md5=8d5cfe9bdd3553fdbd1bc4e52c0228e8; http://www.ncbi.nlm.nih.gov/pubmed/22104143; http://cmuir.cmu.ac.th/handle/6653943832/2968
• Institution: Chiang Mai University

The proximal promoter region of the human vascular endothelial growth factor (VEGF) gene contains a guanine-rich strand that can act as a transcriptional silencer by forming an intramolecular G-quadruplex. In this study, we compared two perylene monoimide derivatives, PM1 and PM2, with the well-stud...