Prenatal diagnosis of beta-thalassemia major by high-performance liquid chromatography analysis of hemoglobins in fetal blood samples

• Main Authors: Sanguansermsri T., Thanarattanakorn P., Steger HF., Tongsong T., Chanprapaph P., Wanpirak C., Siriwatanapa P., Sirichotiyakul S., Flatz G.
• Format: Evaluation Studies
• Language: English
• Published: 2014
• Online Access: http://www.ncbi.nlm.nih.gov/pubmed/3502482; http://cmuir.cmu.ac.th/handle/6653943832/3282
• Institution: Chiang Mai University

In Thailand and adjacent countries, most of the beta-thalassemia genes are beta(0)-thalassemia mutations that prevent the production of Hb A. We propose the quantitation of the Hb A fraction in fetal blood in the mid-trimester of pregnancy by automated high performance liquid chromatography as a rea...