Neuropharmacological activities of the crude alkaloidal fraction from stems of Tabernaemontana pandacaqui Poir
The crude alkaloidal (CA) fraction from the stem of Tabernaemontana pandacaqui Poir. was studied for its pharmacological activity on the central nervous system (CNS) of animals. The CA fraction was found to produce symptoms of CNS depression in conscious rats and mice, viz. reduction in spontaneous...
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2014
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th-cmuir.6653943832-33892014-08-30T02:26:04Z Neuropharmacological activities of the crude alkaloidal fraction from stems of Tabernaemontana pandacaqui Poir Taesotikul T. Panthong A. Kanjanapothi D. Verpoorte R. Scheffer JJ. The crude alkaloidal (CA) fraction from the stem of Tabernaemontana pandacaqui Poir. was studied for its pharmacological activity on the central nervous system (CNS) of animals. The CA fraction was found to produce symptoms of CNS depression in conscious rats and mice, viz. reduction in spontaneous motility, potentiation of pentobarbital sleeping time, prolongation of latency of convulsions induced by pentylenetetrazole and antinociception. However, the fraction could not antagonize oxotremorine-induced tremor. The observations suggest that the CA fraction possesses a CNS depressant activity. 2014-08-30T02:26:04Z 2014-08-30T02:26:04Z 1998 Journal Article 0378-8741 9849633 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3389 eng |
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English |
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The crude alkaloidal (CA) fraction from the stem of Tabernaemontana pandacaqui Poir. was studied for its pharmacological activity on the central nervous system (CNS) of animals. The CA fraction was found to produce symptoms of CNS depression in conscious rats and mice, viz. reduction in spontaneous motility, potentiation of pentobarbital sleeping time, prolongation of latency of convulsions induced by pentylenetetrazole and antinociception. However, the fraction could not antagonize oxotremorine-induced tremor. The observations suggest that the CA fraction possesses a CNS depressant activity. |
| format |
Article |
| author |
Taesotikul T. Panthong A. Kanjanapothi D. Verpoorte R. Scheffer JJ. |
| spellingShingle |
Taesotikul T. Panthong A. Kanjanapothi D. Verpoorte R. Scheffer JJ. Neuropharmacological activities of the crude alkaloidal fraction from stems of Tabernaemontana pandacaqui Poir |
| author_facet |
Taesotikul T. Panthong A. Kanjanapothi D. Verpoorte R. Scheffer JJ. |
| author_sort |
Taesotikul T. |
| title |
Neuropharmacological activities of the crude alkaloidal fraction from stems of Tabernaemontana pandacaqui Poir |
| title_short |
Neuropharmacological activities of the crude alkaloidal fraction from stems of Tabernaemontana pandacaqui Poir |
| title_full |
Neuropharmacological activities of the crude alkaloidal fraction from stems of Tabernaemontana pandacaqui Poir |
| title_fullStr |
Neuropharmacological activities of the crude alkaloidal fraction from stems of Tabernaemontana pandacaqui Poir |
| title_full_unstemmed |
Neuropharmacological activities of the crude alkaloidal fraction from stems of Tabernaemontana pandacaqui Poir |
| title_sort |
neuropharmacological activities of the crude alkaloidal fraction from stems of tabernaemontana pandacaqui poir |
| publishDate |
2014 |
| url |
http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3389 |
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1681420038907625472 |