Cardiovascular effects of Tabernaemontana pandacaqui

Intravenous injection of ethanolic extracts of the stem, leaf and flower of Tabernaemontana pandacaqui caused hypotension in pentobarbital anesthetized rats. At high doses (100-300 mg/kg), the flower extract showed a transient hypertensive effect preceeding hypotensive activity. The effects of the e...

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Main Authors: Taesotikul T., Panthong A., Kanjanapothi D., Verpoorte R., Scheffer JJ.
Format: Article
Language:English
Published: 2014
Online Access:http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3579
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-35792014-08-30T02:35:04Z Cardiovascular effects of Tabernaemontana pandacaqui Taesotikul T. Panthong A. Kanjanapothi D. Verpoorte R. Scheffer JJ. Intravenous injection of ethanolic extracts of the stem, leaf and flower of Tabernaemontana pandacaqui caused hypotension in pentobarbital anesthetized rats. At high doses (100-300 mg/kg), the flower extract showed a transient hypertensive effect preceeding hypotensive activity. The effects of the extracts on the heart rate of anesthetized rats correlated well with the negative chronotropic and inotropic activity observed with isolated atrium. The hypotensive activity was not inhibited by antihistaminic and antimuscarinic agents. The extracts had no effect on the pressor effects induced by norepinephrine or dual carotid occlusion. These results suggest that the hypotensive action of the extracts is not mediated through histaminic and muscarinic receptors stimulation, alpha-adrenoceptor blockade or interference of sympathetic transmission. 2014-08-30T02:35:04Z 2014-08-30T02:35:04Z 1989 Journal Article 0378-8741 2615414 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3579 eng
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Intravenous injection of ethanolic extracts of the stem, leaf and flower of Tabernaemontana pandacaqui caused hypotension in pentobarbital anesthetized rats. At high doses (100-300 mg/kg), the flower extract showed a transient hypertensive effect preceeding hypotensive activity. The effects of the extracts on the heart rate of anesthetized rats correlated well with the negative chronotropic and inotropic activity observed with isolated atrium. The hypotensive activity was not inhibited by antihistaminic and antimuscarinic agents. The extracts had no effect on the pressor effects induced by norepinephrine or dual carotid occlusion. These results suggest that the hypotensive action of the extracts is not mediated through histaminic and muscarinic receptors stimulation, alpha-adrenoceptor blockade or interference of sympathetic transmission.
format Article
author Taesotikul T.
Panthong A.
Kanjanapothi D.
Verpoorte R.
Scheffer JJ.
spellingShingle Taesotikul T.
Panthong A.
Kanjanapothi D.
Verpoorte R.
Scheffer JJ.
Cardiovascular effects of Tabernaemontana pandacaqui
author_facet Taesotikul T.
Panthong A.
Kanjanapothi D.
Verpoorte R.
Scheffer JJ.
author_sort Taesotikul T.
title Cardiovascular effects of Tabernaemontana pandacaqui
title_short Cardiovascular effects of Tabernaemontana pandacaqui
title_full Cardiovascular effects of Tabernaemontana pandacaqui
title_fullStr Cardiovascular effects of Tabernaemontana pandacaqui
title_full_unstemmed Cardiovascular effects of Tabernaemontana pandacaqui
title_sort cardiovascular effects of tabernaemontana pandacaqui
publishDate 2014
url http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3579
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