Cardiovascular effects of Tabernaemontana pandacaqui
Intravenous injection of ethanolic extracts of the stem, leaf and flower of Tabernaemontana pandacaqui caused hypotension in pentobarbital anesthetized rats. At high doses (100-300 mg/kg), the flower extract showed a transient hypertensive effect preceeding hypotensive activity. The effects of the e...
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th-cmuir.6653943832-35792014-08-30T02:35:04Z Cardiovascular effects of Tabernaemontana pandacaqui Taesotikul T. Panthong A. Kanjanapothi D. Verpoorte R. Scheffer JJ. Intravenous injection of ethanolic extracts of the stem, leaf and flower of Tabernaemontana pandacaqui caused hypotension in pentobarbital anesthetized rats. At high doses (100-300 mg/kg), the flower extract showed a transient hypertensive effect preceeding hypotensive activity. The effects of the extracts on the heart rate of anesthetized rats correlated well with the negative chronotropic and inotropic activity observed with isolated atrium. The hypotensive activity was not inhibited by antihistaminic and antimuscarinic agents. The extracts had no effect on the pressor effects induced by norepinephrine or dual carotid occlusion. These results suggest that the hypotensive action of the extracts is not mediated through histaminic and muscarinic receptors stimulation, alpha-adrenoceptor blockade or interference of sympathetic transmission. 2014-08-30T02:35:04Z 2014-08-30T02:35:04Z 1989 Journal Article 0378-8741 2615414 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3579 eng |
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Intravenous injection of ethanolic extracts of the stem, leaf and flower of Tabernaemontana pandacaqui caused hypotension in pentobarbital anesthetized rats. At high doses (100-300 mg/kg), the flower extract showed a transient hypertensive effect preceeding hypotensive activity. The effects of the extracts on the heart rate of anesthetized rats correlated well with the negative chronotropic and inotropic activity observed with isolated atrium. The hypotensive activity was not inhibited by antihistaminic and antimuscarinic agents. The extracts had no effect on the pressor effects induced by norepinephrine or dual carotid occlusion. These results suggest that the hypotensive action of the extracts is not mediated through histaminic and muscarinic receptors stimulation, alpha-adrenoceptor blockade or interference of sympathetic transmission. |
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Article |
author |
Taesotikul T. Panthong A. Kanjanapothi D. Verpoorte R. Scheffer JJ. |
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Taesotikul T. Panthong A. Kanjanapothi D. Verpoorte R. Scheffer JJ. Cardiovascular effects of Tabernaemontana pandacaqui |
author_facet |
Taesotikul T. Panthong A. Kanjanapothi D. Verpoorte R. Scheffer JJ. |
author_sort |
Taesotikul T. |
title |
Cardiovascular effects of Tabernaemontana pandacaqui |
title_short |
Cardiovascular effects of Tabernaemontana pandacaqui |
title_full |
Cardiovascular effects of Tabernaemontana pandacaqui |
title_fullStr |
Cardiovascular effects of Tabernaemontana pandacaqui |
title_full_unstemmed |
Cardiovascular effects of Tabernaemontana pandacaqui |
title_sort |
cardiovascular effects of tabernaemontana pandacaqui |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3579 |
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1681420074795139072 |