Analysis of real-time PCR cycle threshold of α-thalassemia-1 southeast asian type deletion using fetal cell-free DNA in maternal plasma for noninvasive prenatal diagnosis of bart's hydrops fetalis

• Main Authors: Pornprasert S., Sukunthamala K., Kunyanone N., Sittiprasert S., Thungkham K., Junorse S., Pongsawatkul K., Pattanaporn W., Jitwong C., Sanguansermsri T.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-78649272558&partnerID=40&md5=b7e8befb9af677fd29ff83143e0461b1; http://cmuir.cmu.ac.th/handle/6653943832/3621
• Institution: Chiang Mai University

Background: Noninvasive prenatal diagnosis based on detection of fetal cell-free DNA is hampered when mother and father are both carriers for the same autosomal recessive mutation. Objective: To compare the diagnosis of Bart's hydrops fetalis using conventional Gap-PCR analysis of fetal cells/t...