A dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways

• Main Authors: Phromnoi K., Reuter S., Sung B., Limtrakul P., Aggarwal B.B.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-77958572996&partnerID=40&md5=180060881a1015f01946638563c16c99; http://cmuir.cmu.ac.th/handle/6653943832/3634
• Institution: Chiang Mai University

We sought to determine the molecular basis for the anticancer activities of 5,3′-dihydroxy-3,6,7,8,4′-penta-methoxyflavone (DH-PMF), isolated from Gardenia obtusifolia traditionally used in Thailand for a variety of ailments. As little as 1 μM DH-PMF inhibited the proliferation of prostate, colon, k...