Development of a mouse monoclonal antibody against the chondroitin sulfate-protein linkage region derived from shark cartilage

• Main Authors: Akatsu C., Fongmoon D., Mizumoto S., Jacquinet J.-C., Kongtawelert P., Yamada S., Sugahara K.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-77955599594&partnerID=40&md5=c6d97ceb804738d632d3fbcc5c8bc26a; http://cmuir.cmu.ac.th/handle/6653943832/3666
• Institution: Chiang Mai University

Glycosaminoglycans (GAGs) like chondroitin sulfate (CS) and heparan sulfate (HS) are synthesized on the tetrasaccharide linkage region, GlcAβ1-3Galβ1-3Galβ1-4Xylβ1-O-Ser, of proteoglycans. The Xyl can be modified by 2-O-phosphate in both CS and HS, whereas the Gal residues can be sulfated at C-4 and...