Simple and sensitive liquid chromatography-tandem mass spectrometry methods for quantification of paraquat in plasma and urine: Application to experimental and clinical toxicological studies

• Main Authors: Wunnapuk K., Medley G.A., Liu X., Grice J.E., Jayasinghe S., Gawarammana I., Buckley N.A., Roberts M.S.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-80053568460&partnerID=40&md5=f08df726cc1505c2f31b1559b6d7ad47; http://cmuir.cmu.ac.th/handle/6653943832/3719
• Institution: Chiang Mai University

Simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods have been developed and validated for quantification of paraquat (PQ) in plasma and urine. Plasma and urine sample preparation were carried out by one-step protein precipitation using cold acetonitrile (...