Simple and sensitive liquid chromatography-tandem mass spectrometry methods for quantification of paraquat in plasma and urine: Application to experimental and clinical toxicological studies

• Main Authors: Klintean Wunnapuk, Gregory A. Medley, Xin Liu, Jeffrey E. Grice, Sudheera Jayasinghe, Indika Gawarammana, Nicholas A. Buckley, Michael S. Roberts
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80053568460&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49678
• Institution: Chiang Mai University

Simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods have been developed and validated for quantification of paraquat (PQ) in plasma and urine. Plasma and urine sample preparation were carried out by one-step protein precipitation using cold acetonitrile (...