Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

• Main Authors: Somsak V., Uthaipibull C., Prommana P., Srichairatanakool S., Yuthavong Y., Kamchonwongpaisan S.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-80053530568&partnerID=40&md5=bf890731cf169d34109b015b3902fb19; http://cmuir.cmu.ac.th/handle/6653943832/3720
• Institution: Chiang Mai University

Background: Plasmodium vivax is the most prevalent cause of human malaria in tropical regions outside the African continent. The lack of a routine continuous in vitro culture of this parasite makes it difficult to develop specific drugs for this disease. To facilitate the development of anti-P. viva...