Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf

• Main Authors: Pitchakarn P., Suzuki S., Ogawa K., Pompimon W., Takahashi S., Asamoto M., Limtrakul P., Shirai T.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-79955465233&partnerID=40&md5=af5f64f0492076fb9bd6c7555d032606; http://cmuir.cmu.ac.th/handle/6653943832/3739
• Institution: Chiang Mai University

In this study, we focused on the effects of a bitter melon (Momordica charantia) leaf extract (BMLE) and a purified component, Kuguacin J (KuJ), on androgen-dependent LNCaP human prostate cancer cells. Both treatments exerted growth inhibition through G1 arrest and induction of apoptosis. In additio...