Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model

• Main Authors: Tipsuwan W., Srichairatanakool S., Kamchonwongpaisan S., Yuthavong Y., Uthaipibull C.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-79955732820&partnerID=40&md5=e212f440c5fad5dba0ed7e0319d597a9; http://cmuir.cmu.ac.th/handle/6653943832/3758
• Institution: Chiang Mai University

Background: The prevalence of drug resistance amongst the human malaria Plasmodium species has most commonly been associated with genomic mutation within the parasites. This phenomenon necessitates evolutionary predictive studies of possible resistance mutations, which may occur when a new drug is i...