Effect of a novel oral active iron chelator: 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in iron-overloaded and non-overloaded mice

• Main Authors: Chansiw N., Pangjit K., Phisalaphong C., Porter J.B., Evans P., Fucharoen S., Srichairatanakool S.
• Format: Article
• Language: English
• Published: Elsevier (Singapore) Pte Ltd 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84908174801&partnerID=40&md5=e9cee701de687080bb4d9bf71ec05f1c; http://cmuir.cmu.ac.th/handle/6653943832/37617
• Institution: Chiang Mai University

Objective: To evaluate efficacy and toxicity of a novel orally active bidentate iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in mice under normal and iron overload conditions. Methods: Wild type C57BL/6 mice were fed with normal and 0.2% (w/w) ferrocene-supplemented...