Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites

Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites

The ethanolic extract of Clerodendrum petasites was tested to evaluate the spasmolytic activity on isolated guinea-pig tracheal smooth muscle. The crude extract (2.25-9.0 mg/ml) dose-dependently caused relaxation of tracheal smooth muscle which was contracted by exposure to histamine. A bioassay-gui...

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Main Authors: Hazekamp A., Verpoorte R., Panthong A.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-0034811614&partnerID=40&md5=4a128a19195a79a5c6dff9a28442d13c
http://cmuir.cmu.ac.th/handle/6653943832/3786
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-37862014-08-30T02:35:19Z Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites Hazekamp A. Verpoorte R. Panthong A. The ethanolic extract of Clerodendrum petasites was tested to evaluate the spasmolytic activity on isolated guinea-pig tracheal smooth muscle. The crude extract (2.25-9.0 mg/ml) dose-dependently caused relaxation of tracheal smooth muscle which was contracted by exposure to histamine. A bioassay-guided fractionation of the crude extract was performed by means of partitioning and centrifugal partition chromatography. Finally the active principle was isolated and identified as the flavonoid hispidulin (EC50: (3.0±0.8)×10-5 M). These results suggest that hispidulin may be beneficial in the treatment of asthma. © 2001 Elsevier Science Ireland Ltd. All rights reserved. 2014-08-30T02:35:19Z 2014-08-30T02:35:19Z 2001 Article 03788741 10.1016/S0378-8741(01)00320-8 11585687 JOETD http://www.scopus.com/inward/record.url?eid=2-s2.0-0034811614&partnerID=40&md5=4a128a19195a79a5c6dff9a28442d13c http://cmuir.cmu.ac.th/handle/6653943832/3786 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description The ethanolic extract of Clerodendrum petasites was tested to evaluate the spasmolytic activity on isolated guinea-pig tracheal smooth muscle. The crude extract (2.25-9.0 mg/ml) dose-dependently caused relaxation of tracheal smooth muscle which was contracted by exposure to histamine. A bioassay-guided fractionation of the crude extract was performed by means of partitioning and centrifugal partition chromatography. Finally the active principle was isolated and identified as the flavonoid hispidulin (EC50: (3.0±0.8)×10-5 M). These results suggest that hispidulin may be beneficial in the treatment of asthma. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
format Article
author Hazekamp A.
Verpoorte R.
Panthong A.
spellingShingle Hazekamp A.
Verpoorte R.
Panthong A.
Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites
author_facet Hazekamp A.
Verpoorte R.
Panthong A.
author_sort Hazekamp A.
title Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites
title_short Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites
title_full Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites
title_fullStr Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites
title_full_unstemmed Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites
title_sort isolation of a bronchodilator flavonoid from the thai medicinal plant clerodendrum petasites
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-0034811614&partnerID=40&md5=4a128a19195a79a5c6dff9a28442d13c
http://cmuir.cmu.ac.th/handle/6653943832/3786
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