Expression of sodium channels in dental pulp

Background: Several isoforms of voltage-gated sodium channels (VGSCs) found in peripheral nerves is associated in the pathogenesis of neuropathic and inflammatory pain. Until now, there are few studies of the distribution of VGSCs in dental pulp and its relationship to dental pain. Objective: Perfor...

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Main Authors: Suwanchai,A., Theerapiboon,U., Chattipakorn,N., Chattipakorn,S.C.
Format: Review
Published: IOS Press 2015
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http://cmuir.cmu.ac.th/handle/6653943832/37991
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-379912015-06-16T03:59:32Z Expression of sodium channels in dental pulp Suwanchai,A. Theerapiboon,U. Chattipakorn,N. Chattipakorn,S.C. Medicine (all) Biochemistry, Genetics and Molecular Biology (all) Background: Several isoforms of voltage-gated sodium channels (VGSCs) found in peripheral nerves is associated in the pathogenesis of neuropathic and inflammatory pain. Until now, there are few studies of the distribution of VGSCs in dental pulp and its relationship to dental pain. Objective: Perform literature review to provide update information of VGSCs in dental pulp. Methods: We reviewed and discussed seventy-eight articles listed in MEDLINE (PubMed) database using keywords including "sodium channels" and "dental pain". They are articles published in English from 1978 to 2010. Results: Although several VGSCs isoforms are distributed in dental pulp, only NaV1.7, NaV1.8, and NaV1.9 have been found to be upregulated in painful pulpitis. Conclusion: NaV1.7, Na V1.8, and NaV1.9 seem to have key roles in inflammatory dental pain. As a result, they might be the targets to treat dental pulp inflammation. 2015-06-16T03:59:32Z 2015-06-16T03:59:32Z 2011-12-01 Review 19057415 2-s2.0-84871674569 10.5372/1905-7415.0506.100 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84871674569&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/37991 IOS Press
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine (all)
Biochemistry, Genetics and Molecular Biology (all)
spellingShingle Medicine (all)
Biochemistry, Genetics and Molecular Biology (all)
Suwanchai,A.
Theerapiboon,U.
Chattipakorn,N.
Chattipakorn,S.C.
Expression of sodium channels in dental pulp
description Background: Several isoforms of voltage-gated sodium channels (VGSCs) found in peripheral nerves is associated in the pathogenesis of neuropathic and inflammatory pain. Until now, there are few studies of the distribution of VGSCs in dental pulp and its relationship to dental pain. Objective: Perform literature review to provide update information of VGSCs in dental pulp. Methods: We reviewed and discussed seventy-eight articles listed in MEDLINE (PubMed) database using keywords including "sodium channels" and "dental pain". They are articles published in English from 1978 to 2010. Results: Although several VGSCs isoforms are distributed in dental pulp, only NaV1.7, NaV1.8, and NaV1.9 have been found to be upregulated in painful pulpitis. Conclusion: NaV1.7, Na V1.8, and NaV1.9 seem to have key roles in inflammatory dental pain. As a result, they might be the targets to treat dental pulp inflammation.
format Review
author Suwanchai,A.
Theerapiboon,U.
Chattipakorn,N.
Chattipakorn,S.C.
author_facet Suwanchai,A.
Theerapiboon,U.
Chattipakorn,N.
Chattipakorn,S.C.
author_sort Suwanchai,A.
title Expression of sodium channels in dental pulp
title_short Expression of sodium channels in dental pulp
title_full Expression of sodium channels in dental pulp
title_fullStr Expression of sodium channels in dental pulp
title_full_unstemmed Expression of sodium channels in dental pulp
title_sort expression of sodium channels in dental pulp
publisher IOS Press
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84871674569&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/37991
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