Mitochondrial calcium uniporter blocker prevents cardiac mitochondrial dysfunction induced by iron overload in thalassemic mice

• Main Authors: Kumfu S., Chattipakorn S., Fucharoen S., Chattipakorn N.
• Format: Article
• Published: Springer Netherlands 2015
• Subjects: Metals and Alloys; Biochemistry, Genetics and Molecular Biology (all); Biomaterials; Agricultural and Biological Sciences (all)
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84874112168&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38261
• Institution: Chiang Mai University

Iron-overload induced cardiomyopathy is a major cause of morbidity and mortality in thalassemic patients. Previous studies suggest that cardiac mitochondrial dysfunction may be involved in the pathogenesis of cardiomyopathy in thalassemia. We tested the hypothesis that iron overload causes dysfuncti...