Down-regulation of the human VEGF gene expression by perylene monoimide derivatives

• Main Authors: Taka,T., Joonlasak,K., Huang,L., Randall Lee,T., Chang,S.W.T., Tuntiwechapikul,W.
• Format: Article
• Published: Elsevier Limited 2015
• Subjects: Clinical Biochemistry; Drug Discovery; Pharmaceutical Science; Molecular Medicine; Molecular Biology; Organic Chemistry; Biochemistry
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84655169275&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38184
• Institution: Chiang Mai University

The proximal promoter region of the human vascular endothelial growth factor (VEGF) gene contains a guanine-rich strand that can act as a transcriptional silencer by forming an intramolecular G-quadruplex. In this study, we compared two perylene monoimide derivatives, PM1 and PM2, with the well-stud...