Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells

• Main Authors: Thanachai Taka, Liming Huang, Ariyaphong Wongnoppavich, Suk Wah Tam-Chang, T. Randall Lee, Wirote Tuntiwechapikul
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873312526&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52271
• Institution: Chiang Mai University

Cancer cells evade replicative senescence by re-expressing telomerase, which maintains telomere length and hence chromosomal integrity. Telomerase inhibition would lead cancer cells to senesce and therefore prevent cancer cells from growing indefinitely. G-quadruplex ligands can attenuate telomerase...