Correlation of CYP2B6-516G>T polymorphism with plasma efavirenz concentration and depression in HIV-infected adults in Northern Thailand

• Main Authors: Aurpibul,L., Chotirosniramit,N., Sugandhavesa,P., Kosashunhanan,N., Thetket,S., Supindham,T., Piyamongkol,W., Supparatpinyo,K.
• Format: Article
• Published: Bentham Science Publishers B.V. 2015
• Subjects: Infectious Diseases; Virology
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84872553328&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38248
• Institution: Chiang Mai University

Background: Single nucleotide polymorphism of the hepatic cytochrome P450 isoenzyme 2B6 (CYP2B6) gene is a cause of variation in plasma efavirenz (EFV) concentrations. We aimed to determine the allelic distribution of CYP2B6 gene, plasma levels of EFV, the prevalence of clinical depression, and thei...