Hepatotoxicity in a 52-week randomized trial of short-term versus long-term treatment with buprenorphine/naloxone in HIV-negative injection opioid users in China and Thailand

• Main Authors: Lucas G., Young A., Donnell D., Richardson P., Aramrattana A., Shao Y., Ruan Y., Liu W., Fu L., Ma J., Celentano D., Metzger D., Jackson J., Burns D.
• Format: Article
• Published: Elsevier Ireland Ltd 2015
• Subjects: Toxicology; Pharmacology; Pharmacology (medical); Psychiatry and Mental Health
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84905565999&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38292
• Institution: Chiang Mai University

Background: Buprenorphine/naloxone (BUP/NX), an effective treatment for opioid dependence, has been implicated in hepatic toxicity. However, as persons taking BUP/NX have multiple hepatic risk factors, comparative data are needed to quantify the risk of hepatoxicity with BUP/NX. Methods: We compared...