Sawtehtetronenin from goniothalamus sawtehii and its cytotoxicity
Copyright © 2014 Natural Product Communciations Inc. A new acetogenin has been isolated from the ethyl acetate extract of leaves and twigs of G. Sawtehii (Annonaceae). The structure of compound 1 was identified as sawtehtetronenin on the basis of spectral evidence (UV, IR, MS and 1H, and 13C NMR) an...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
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Natural Product Communications
2015
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| Subjects: | |
| Online Access: | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84920401761&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38360 |
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| Institution: | Chiang Mai University |
| Summary: | Copyright © 2014 Natural Product Communciations Inc. A new acetogenin has been isolated from the ethyl acetate extract of leaves and twigs of G. Sawtehii (Annonaceae). The structure of compound 1 was identified as sawtehtetronenin on the basis of spectral evidence (UV, IR, MS and 1H, and 13C NMR) and by comparison with related compounds. Sawtehtetronenin was found to be cytotoxic to human hepatocellular carcinoma HepG2 and breast cancer MDA-MB231 cells with IC50 values of 79.3+11.9 μM and 108.1+1.5 μM, respectively. Compound 1 was less toxic to both cell lines when compared with camptothecin, a chemotherapeutic drug. |
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