Sawtehtetronenin from goniothalamus sawtehii and its cytotoxicity

Sawtehtetronenin from goniothalamus sawtehii and its cytotoxicity

Copyright © 2014 Natural Product Communciations Inc. A new acetogenin has been isolated from the ethyl acetate extract of leaves and twigs of G. Sawtehii (Annonaceae). The structure of compound 1 was identified as sawtehtetronenin on the basis of spectral evidence (UV, IR, MS and 1H, and 13C NMR) an...

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Main Authors: Thiplueang,C., Punyanitya,S., Banjerdpongchai,R., Wudtiwai,B., Udomputtimekakul,P., Buayairaksa,M., Nuntasaen,N., Pompimon,W.
Format: Article
Published: Natural Product Communications 2015
Subjects:
Plant Science
Drug Discovery
Pharmacology
Complementary and Alternative Medicine
Online Access:http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84920401761&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38360
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Institution: Chiang Mai University
id th-cmuir.6653943832-38360
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spelling th-cmuir.6653943832-383602015-06-16T07:47:03Z Sawtehtetronenin from goniothalamus sawtehii and its cytotoxicity Thiplueang,C. Punyanitya,S. Banjerdpongchai,R. Wudtiwai,B. Udomputtimekakul,P. Buayairaksa,M. Nuntasaen,N. Pompimon,W. Plant Science Drug Discovery Pharmacology Complementary and Alternative Medicine Copyright © 2014 Natural Product Communciations Inc. A new acetogenin has been isolated from the ethyl acetate extract of leaves and twigs of G. Sawtehii (Annonaceae). The structure of compound 1 was identified as sawtehtetronenin on the basis of spectral evidence (UV, IR, MS and 1H, and 13C NMR) and by comparison with related compounds. Sawtehtetronenin was found to be cytotoxic to human hepatocellular carcinoma HepG2 and breast cancer MDA-MB231 cells with IC50 values of 79.3+11.9 μM and 108.1+1.5 μM, respectively. Compound 1 was less toxic to both cell lines when compared with camptothecin, a chemotherapeutic drug. 2015-06-16T07:47:03Z 2015-06-16T07:47:03Z 2014-01-01 Article 1934578X 2-s2.0-84920401761 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84920401761&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38360 Natural Product Communications
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Plant Science
Drug Discovery
Pharmacology
Complementary and Alternative Medicine
spellingShingle Plant Science
Drug Discovery
Pharmacology
Complementary and Alternative Medicine
Thiplueang,C.
Punyanitya,S.
Banjerdpongchai,R.
Wudtiwai,B.
Udomputtimekakul,P.
Buayairaksa,M.
Nuntasaen,N.
Pompimon,W.
Sawtehtetronenin from goniothalamus sawtehii and its cytotoxicity
description Copyright © 2014 Natural Product Communciations Inc. A new acetogenin has been isolated from the ethyl acetate extract of leaves and twigs of G. Sawtehii (Annonaceae). The structure of compound 1 was identified as sawtehtetronenin on the basis of spectral evidence (UV, IR, MS and 1H, and 13C NMR) and by comparison with related compounds. Sawtehtetronenin was found to be cytotoxic to human hepatocellular carcinoma HepG2 and breast cancer MDA-MB231 cells with IC50 values of 79.3+11.9 μM and 108.1+1.5 μM, respectively. Compound 1 was less toxic to both cell lines when compared with camptothecin, a chemotherapeutic drug.
format Article
author Thiplueang,C.
Punyanitya,S.
Banjerdpongchai,R.
Wudtiwai,B.
Udomputtimekakul,P.
Buayairaksa,M.
Nuntasaen,N.
Pompimon,W.
author_facet Thiplueang,C.
Punyanitya,S.
Banjerdpongchai,R.
Wudtiwai,B.
Udomputtimekakul,P.
Buayairaksa,M.
Nuntasaen,N.
Pompimon,W.
author_sort Thiplueang,C.
title Sawtehtetronenin from goniothalamus sawtehii and its cytotoxicity
title_short Sawtehtetronenin from goniothalamus sawtehii and its cytotoxicity
title_full Sawtehtetronenin from goniothalamus sawtehii and its cytotoxicity
title_fullStr Sawtehtetronenin from goniothalamus sawtehii and its cytotoxicity
title_full_unstemmed Sawtehtetronenin from goniothalamus sawtehii and its cytotoxicity
title_sort sawtehtetronenin from goniothalamus sawtehii and its cytotoxicity
publisher Natural Product Communications
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84920401761&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38360
_version_ 1681421459528876032

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