Influence of amino acid variations in the NS3, NS4A and NS4B of HCV genotypes 1a, 1b, 3a, 3b and 6f on the response to pegylated interferon and ribavirin combination therapy

• Main Authors: Chusri,P., Kumthip,K., Pantip,C., Thongsawat,S., O'Brien,A., Maneekarn,N.
• Format: Article
• Published: Elsevier 2015
• Subjects: Cancer Research; Infectious Diseases; Virology
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84920735754&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38364
• Institution: Chiang Mai University

© 2014 Elsevier B.V. Background: It has been suggested that HCV proteins, core, NS3/4A, NS4B, and NS5A, contribute to the resistance of HCV to IFN and ribavirin (RBV) treatments. Aim: To assess the effects of HCV amino acid variations in NS3, NS4A and NS4B of HCV subtypes 1a, 1b, 3a, 3b and 6f on th...