Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3

• Main Authors: Phoo, Wint Wint, El Sahili, Abbas, Zhang, ZhenZhen, Chen, Ming Wei, Liew, Chong Wai, Lescar, Julien, Vasudevan, Subhash G., Luo, Dahai
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Flavivirus NS3; Anti Viral Drug Discovery
• Online Access: https://hdl.handle.net/10356/154890
• Institution: Nanyang Technological University

Flavivirus is a genus of the Flaviviridae family which includes significant emerging and re-emerging human disease-causing arboviruses such as dengue and Zika viruses. Flaviviral non-structural protein 3 (NS3) protease-helicase plays essential roles in viral replication and is an attractive antivira...