Stigmalactam from Orophea enterocarpa induces human cancer cell apoptosis via a mitochondrial pathway

• Main Authors: Banjerdpongchai,R., Wudtiwai,B., Pompimon,W.
• Format: Article
• Published: Asian Pacific Organization for Cancer Prevention 2015
• Subjects: Cancer Research; Oncology; Epidemiology; Public Health, Environmental and Occupational Health
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84921764192&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38371
• Institution: Chiang Mai University

Stigmalactam, an aristolactam-type alkaloid extracted from Orophea enterocarpa, exerts cytotoxicity against several human and murine cancer cell lines, but the molecular mechanisms remain elusive. The aims of this study were to identify the mode and mechanisms of human cancer cell death induced by s...