Calcium-induced Cardiac Mitochondrial Dysfunction Is Predominantly Mediated by Cyclosporine A-dependent Mitochondrial Permeability Transition Pore But Not Mitochondrial Calcium Uniporter

• Main Authors: Yarana C., Sripetchwandee J., Sanit J., Chattipakorn S., Chattipakorn N.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.ncbi.nlm.nih.gov/pubmed/22824212; http://cmuir.cmu.ac.th/handle/6653943832/3859
• Institution: Chiang Mai University

BACKGROUND AND AIMS: Cardiac mitochondrial Ca(2+) overload plays a critical role in mechanical and electrical dysfunction leading to cardiac cell death and fatal arrhythmia. Because Ca(2+) overload is related to mitochondrial permeability transition, reactive oxygen species (ROS) production and memb...