Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers

Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers

In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has b...

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Main Authors: Phothongkam S., Chancharunee S., Saovapakhiran A., Wichai U., Pohmakotr M.
Format: Article
Published: Elsevier Limited 2015
Subjects:
Clinical Biochemistry
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Molecular Biology
Organic Chemistry
Biochemistry
Online Access:http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870236110&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38648
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-386482015-06-16T07:53:46Z Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers Phothongkam S. Chancharunee S. Saovapakhiran A. Wichai U. Pohmakotr M. Clinical Biochemistry Drug Discovery Pharmaceutical Science Molecular Medicine Molecular Biology Organic Chemistry Biochemistry In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has been performed. The biological activities of all synthesized compounds were evaluated against the colon cancer cell line (Caco-2). The non-acetal deoxoartemisinin monomers 12a, 15a-c and dimers 13a, 16a-c were active against Caco-2 cells and more potent than dihydroartemisinin. © 2012 Elsevier Ltd. All rights reserved. 2015-06-16T07:53:46Z 2015-06-16T07:53:46Z 2012-12-15 Article 0960894X 2-s2.0-84870236110 10.1016/j.bmcl.2012.10.020 23103096 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870236110&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38648 Elsevier Limited
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Clinical Biochemistry
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Molecular Biology
Organic Chemistry
Biochemistry
spellingShingle Clinical Biochemistry
Drug Discovery
Pharmaceutical Science
Molecular Medicine
Molecular Biology
Organic Chemistry
Biochemistry
Phothongkam S.
Chancharunee S.
Saovapakhiran A.
Wichai U.
Pohmakotr M.
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
description In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has been performed. The biological activities of all synthesized compounds were evaluated against the colon cancer cell line (Caco-2). The non-acetal deoxoartemisinin monomers 12a, 15a-c and dimers 13a, 16a-c were active against Caco-2 cells and more potent than dihydroartemisinin. © 2012 Elsevier Ltd. All rights reserved.
format Article
author Phothongkam S.
Chancharunee S.
Saovapakhiran A.
Wichai U.
Pohmakotr M.
author_facet Phothongkam S.
Chancharunee S.
Saovapakhiran A.
Wichai U.
Pohmakotr M.
author_sort Phothongkam S.
title Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
title_short Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
title_full Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
title_fullStr Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
title_full_unstemmed Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
title_sort facile synthesis and anticancer activity of c-10 non-acetal deoxoartemisinin dimers
publisher Elsevier Limited
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870236110&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38648
_version_ 1681421511709163520

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