Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers

• Main Authors: Phothongkam S., Chancharunee S., Saovapakhiran A., Wichai U., Pohmakotr M.
• Format: Article
• Published: Elsevier Limited 2015
• Subjects: Clinical Biochemistry; Drug Discovery; Pharmaceutical Science; Molecular Medicine; Molecular Biology; Organic Chemistry; Biochemistry
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870236110&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38648
• Institution: Chiang Mai University

In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has b...