Neolignans from leaves of Miliusa mollis

From the leaves of Miliusa mollis Pierre (Annonaceae), five new dihydrobenzofuran neolignans, namely miliumollin, 7-methoxymiliumollin, 3′-methoxymiliumollin, 4′-O-methylmiliumollin and miliumollinone, and a new 8-O-4′ neolignan named miliusamollin were isolated, and their structures were elucidated...

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Main Authors:	Sawasdee,K., Chaowasku,T., Lipipun,V., Dufat,T.H., Michel,S., Likhitwitayawuid,K.
Format:	Article
Published:	Elsevier 2015
Subjects:	Drug Discovery Pharmacology
Online Access:	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84874671600&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38688
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-38688
record_format	dspace
spelling	th-cmuir.6653943832-386882015-06-16T07:53:56Z Neolignans from leaves of Miliusa mollis Sawasdee,K. Chaowasku,T. Lipipun,V. Dufat,T.H. Michel,S. Likhitwitayawuid,K. Drug Discovery Pharmacology From the leaves of Miliusa mollis Pierre (Annonaceae), five new dihydrobenzofuran neolignans, namely miliumollin, 7-methoxymiliumollin, 3′-methoxymiliumollin, 4′-O-methylmiliumollin and miliumollinone, and a new 8-O-4′ neolignan named miliusamollin were isolated, and their structures were elucidated through analysis of spectroscopic data. Miliumollin, 3′-methoxymiliumollin, miliumollinone and decurrenal exhibited weak cytotoxicity against KB, MCF7 and NCI-H187 cells. Miliumollinone possessed weak inhibitory effects against herpes simplex virus types 1 and 2. None of the isolates displayed inhibitory activity against avian influenza H5N1 neuraminidase. © 2013 Elsevier B.V. 2015-06-16T07:53:56Z 2015-06-16T07:53:56Z 2013-03-01 Article 0367326X 2-s2.0-84874671600 10.1016/j.fitote.2012.12.028 23305777 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84874671600&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38688 Elsevier
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Drug Discovery Pharmacology
spellingShingle	Drug Discovery Pharmacology Sawasdee,K. Chaowasku,T. Lipipun,V. Dufat,T.H. Michel,S. Likhitwitayawuid,K. Neolignans from leaves of Miliusa mollis
description	From the leaves of Miliusa mollis Pierre (Annonaceae), five new dihydrobenzofuran neolignans, namely miliumollin, 7-methoxymiliumollin, 3′-methoxymiliumollin, 4′-O-methylmiliumollin and miliumollinone, and a new 8-O-4′ neolignan named miliusamollin were isolated, and their structures were elucidated through analysis of spectroscopic data. Miliumollin, 3′-methoxymiliumollin, miliumollinone and decurrenal exhibited weak cytotoxicity against KB, MCF7 and NCI-H187 cells. Miliumollinone possessed weak inhibitory effects against herpes simplex virus types 1 and 2. None of the isolates displayed inhibitory activity against avian influenza H5N1 neuraminidase. © 2013 Elsevier B.V.
format	Article
author	Sawasdee,K. Chaowasku,T. Lipipun,V. Dufat,T.H. Michel,S. Likhitwitayawuid,K.
author_facet	Sawasdee,K. Chaowasku,T. Lipipun,V. Dufat,T.H. Michel,S. Likhitwitayawuid,K.
author_sort	Sawasdee,K.
title	Neolignans from leaves of Miliusa mollis
title_short	Neolignans from leaves of Miliusa mollis
title_full	Neolignans from leaves of Miliusa mollis
title_fullStr	Neolignans from leaves of Miliusa mollis
title_full_unstemmed	Neolignans from leaves of Miliusa mollis
title_sort	neolignans from leaves of miliusa mollis
publisher	Elsevier
publishDate	2015
url	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84874671600&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38688
_version_	1681421518960066560

Neolignans from leaves of Miliusa mollis

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