Homogeneity of β0-Thalassemia codon 17 (A →T) alleles in Northern Thailand using a direct DNA sequencing method
The aim of this study was to characterize β-globin gene micro-haplotype polymorphisms (frameworks) associated with a β-thalassemia mutations common in Northern Thailand using a direct DNA sequencing method. A total of 11 β-thalassemia major patients homozygous for the codon 17 (A →T) mutation admitt...
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2014
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th-cmuir.6653943832-39532014-08-30T02:35:30Z Homogeneity of β0-Thalassemia codon 17 (A →T) alleles in Northern Thailand using a direct DNA sequencing method Sanguansermsri P. Shimbhu D. Wongvilairat R. Saetung R. Sanguansermsri T. The aim of this study was to characterize β-globin gene micro-haplotype polymorphisms (frameworks) associated with a β-thalassemia mutations common in Northern Thailand using a direct DNA sequencing method. A total of 11 β-thalassemia major patients homozygous for the codon 17 (A →T) mutation admitted to Chiang Mai University Hospital were examined. All 22 alleles were found to contain the Asian framework 3 A. The homogeneity of the framework associated with the codon 17 (A →T) mutation indicates a relatively recent origin of the codon 17 (A →T) mutation. Similar studies in other East Asian populations may provide information concerning the origin and the migrational spread of this β-thalassemia mutation. 2014-08-30T02:35:30Z 2014-08-30T02:35:30Z 2004 Article 01252208 15471290 JMTHB http://www.scopus.com/inward/record.url?eid=2-s2.0-4544290183&partnerID=40&md5=7bead9a7f757c59403673281b18a6697 http://cmuir.cmu.ac.th/handle/6653943832/3953 English |
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The aim of this study was to characterize β-globin gene micro-haplotype polymorphisms (frameworks) associated with a β-thalassemia mutations common in Northern Thailand using a direct DNA sequencing method. A total of 11 β-thalassemia major patients homozygous for the codon 17 (A →T) mutation admitted to Chiang Mai University Hospital were examined. All 22 alleles were found to contain the Asian framework 3 A. The homogeneity of the framework associated with the codon 17 (A →T) mutation indicates a relatively recent origin of the codon 17 (A →T) mutation. Similar studies in other East Asian populations may provide information concerning the origin and the migrational spread of this β-thalassemia mutation. |
| format |
Article |
| author |
Sanguansermsri P. Shimbhu D. Wongvilairat R. Saetung R. Sanguansermsri T. |
| spellingShingle |
Sanguansermsri P. Shimbhu D. Wongvilairat R. Saetung R. Sanguansermsri T. Homogeneity of β0-Thalassemia codon 17 (A →T) alleles in Northern Thailand using a direct DNA sequencing method |
| author_facet |
Sanguansermsri P. Shimbhu D. Wongvilairat R. Saetung R. Sanguansermsri T. |
| author_sort |
Sanguansermsri P. |
| title |
Homogeneity of β0-Thalassemia codon 17 (A →T) alleles in Northern Thailand using a direct DNA sequencing method |
| title_short |
Homogeneity of β0-Thalassemia codon 17 (A →T) alleles in Northern Thailand using a direct DNA sequencing method |
| title_full |
Homogeneity of β0-Thalassemia codon 17 (A →T) alleles in Northern Thailand using a direct DNA sequencing method |
| title_fullStr |
Homogeneity of β0-Thalassemia codon 17 (A →T) alleles in Northern Thailand using a direct DNA sequencing method |
| title_full_unstemmed |
Homogeneity of β0-Thalassemia codon 17 (A →T) alleles in Northern Thailand using a direct DNA sequencing method |
| title_sort |
homogeneity of β0-thalassemia codon 17 (a →t) alleles in northern thailand using a direct dna sequencing method |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-4544290183&partnerID=40&md5=7bead9a7f757c59403673281b18a6697 http://cmuir.cmu.ac.th/handle/6653943832/3953 |
| _version_ |
1681420145914806272 |