Nucleotide binding domain 1 pharmacophore modeling for visualization and analysis of P-glycoprotein–flavonoid molecular interactions

• Main Authors: Wongrattanakamon P., Lee V., Nimmanpipug P., Jiranusornkul S.
• Format: Journal
• Published: 2017
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84988662367&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/41472
• Institution: Chiang Mai University

© 2016, Higher Education Press and Springer-Verlag Berlin Heidelberg. Background: P-glycoprotein (P-gp) is a 170-kDa membrane protein. It provides a barrier function and help to excrete toxins from the body as a transporter. Some bioflavonoids have been shown to block P-gp activity. Objective: To ev...