A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload

• Main Authors: Sripetchwandee J., Wongjaikam S., Krintratun W., Chattipakorn N., Chattipakorn S.
• Format: Journal
• Published: 2017
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84978715654&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/41519
• Institution: Chiang Mai University

© 2016 IBRO Iron-overload can cause cognitive impairment due to blood–brain barrier (BBB) breakdown and brain mitochondrial dysfunction. Although deferiprone (DFP) has been shown to exert neuroprotection, the head-to-head comparison among iron chelators used clinically on brain iron-overload has not...