Reactive center loop moiety is essential for the maspin activity on cellular invasion and ubiquitin-proteasome level

• Main Authors: Khanaree C., Chairatvit K., Roytrakul S., Wongnoppavich A.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84880309087&partnerID=40&md5=faaf729eb610f1e4b5ae8c6fb98e936c; http://www.ncbi.nlm.nih.gov/pubmed/23924927; http://cmuir.cmu.ac.th/handle/6653943832/4156
• Institution: Chiang Mai University

Maspin, a tumor suppressor (SERPINB5), inhibits cancer migration, invasion, and metastasis in vitro and in vivo. The tumor-suppressing effects of maspin depend in part on its ability to enhance cell adhesion to extracellular matrix. Although the molecular mechanism of maspin's action is still u...