Cisplatin-induced ototoxicity in pediatric solid tumors: The role of glutathione S-transferases and megalin genetic polymorphisms

• Main Authors: Choeyprasert W., Sawangpanich R., Lertsukprasert K., Udomsubpayakul U., Songdej D., Unurathapan U., Pakakasama S., Hongeng S.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84878653311&partnerID=40&md5=b4a45002649869f05b7628112d98f30f; http://cmuir.cmu.ac.th/handle/6653943832/4170
• Institution: Chiang Mai University

Cisplatin-induced ototoxicity, an important dose-limiting side effect, has proven high interindividual variability. Glutathione S-transferases (GSTs) are isoenzymes involved in cellular detoxification processes. Megalin has been demonstrated to bind aminoglycosides, known to be similar to cisplatin...