Cisplatin-induced ototoxicity in pediatric solid tumors: The role of glutathione S-transferases and megalin genetic polymorphisms

Cisplatin-induced ototoxicity in pediatric solid tumors: The role of glutathione S-transferases and megalin genetic polymorphisms

Cisplatin-induced ototoxicity, an important dose-limiting side effect, has proven high interindividual variability. Glutathione S-transferases (GSTs) are isoenzymes involved in cellular detoxification processes. Megalin has been demonstrated to bind aminoglycosides, known to be similar to cisplatin...

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Main Authors: Worawut Choeyprasert, Rachchadol Sawangpanich, Krisna Lertsukprasert, Umaporn Udomsubpayakul, Duantida Songdej, Usanarat Unurathapan, Samart Pakakasama, Suradej Hongeng
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878653311&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47977
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Institution: Chiang Mai University

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http://cmuir.cmu.ac.th/jspui/handle/6653943832/47977

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