Potent vasorelaxant analogs from chemical modification and biotransformation of isosteviol

• Main Authors: Wonganan O., Tocharus C., Puedsing C., Homvisasevongsa S., Sukcharoen O., Suksamrarn A.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84875987038&partnerID=40&md5=8e960fb167f1307eb2b959bc5a37adbc; http://cmuir.cmu.ac.th/handle/6653943832/4174
• Institution: Chiang Mai University

Isosteviol (1) has been reported to exhibit moderate vasorelaxant activity. In order to enhance the bioactivity of this compound, chemical modification of 1 to the dihydro analog, ent-16β-hydroxybeyeran-19-oic acid (2), was undertaken. Compound 2 was then converted to the corresponding acetate deriv...