Generation and preclinical evaluation of a DENV-1/2 prM+E chimeric live attenuated vaccine candidate with enhanced prM cleavage

• Main Authors: Keelapang P., Nitatpattana N., Suphatrakul A., Punyahathaikul S., Sriburi R., Pulmanausahakul R., Pichyangkul S., Malasit P., Yoksan S., Sittisombut N.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.ncbi.nlm.nih.gov/pubmed/23973247; http://www.scopus.com/inward/record.url?eid=2-s2.0-84885429467&partnerID=40&md5=f7d6e74173b4e786dba863f3ce6d0e04; http://cmuir.cmu.ac.th/handle/6653943832/4187
• Institution: Chiang Mai University

In the absence of a vaccine or sustainable vector control measures, illnesses caused by dengue virus infection remain an important public health problem in many tropical countries. During the export of dengue virus particles, furin-mediated cleavage of the prM envelope protein is usually incomplete,...