Generation and preclinical evaluation of a DENV-1/2 prM+E chimeric live attenuated vaccine candidate with enhanced prM cleavage

Generation and preclinical evaluation of a DENV-1/2 prM+E chimeric live attenuated vaccine candidate with enhanced prM cleavage

In the absence of a vaccine or sustainable vector control measures, illnesses caused by dengue virus infection remain an important public health problem in many tropical countries. During the export of dengue virus particles, furin-mediated cleavage of the prM envelope protein is usually incomplete,...

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Bibliographic Details
Main Authors: Poonsook Keelapang, Narong Nitatpattana, Amporn Suphatrakul, Surat Punyahathaikul, Rungtawan Sriburi, Rojjanaporn Pulmanausahakul, Sathit Pichyangkul, Prida Malasit, Sutee Yoksan, Nopporn Sittisombut
Format: Journal
Published: 2018
Subjects:
Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Medicine
Veterinary
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84885429467&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/52201
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Institution: Chiang Mai University

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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84885429467&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/52201

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