Generation and preclinical evaluation of a DENV-1/2 prM+E chimeric live attenuated vaccine candidate with enhanced prM cleavage

• Main Authors: Poonsook Keelapang, Narong Nitatpattana, Amporn Suphatrakul, Surat Punyahathaikul, Rungtawan Sriburi, Rojjanaporn Pulmanausahakul, Sathit Pichyangkul, Prida Malasit, Sutee Yoksan, Nopporn Sittisombut
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Veterinary
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84885429467&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52201
• Institution: Chiang Mai University

In the absence of a vaccine or sustainable vector control measures, illnesses caused by dengue virus infection remain an important public health problem in many tropical countries. During the export of dengue virus particles, furin-mediated cleavage of the prM envelope protein is usually incomplete,...