HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response

• Main Authors: Chusri P., Kumthip K., Hong J., Zhu C., Duan X., Jilg N., Fusco D., Brisac C., Schaefer E., Cai D., Peng L., Maneekarn N., Lin W., Chung R.
• Format: Journal
• Published: 2017
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84959467728&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/42069
• Institution: Chiang Mai University

HCV replication disrupts normal endoplasmic reticulum (ER) function and activates a signaling network called the unfolded protein response (UPR). UPR is directed by three ER transmembrane proteins including ATF6, IRE1, and PERK. HCV increases TGF-β1 and oxidative stress, which play important roles i...