High-performance liquid chromatographic method for the analysis of fluconazole in pharmaceutical preparations
High-performance liquid chromatographic method was developed for the analysis of fluconazole in pharmaceutical preparations. The analyzed drug was separated on a reversed-phase column [Hypersil ODS column (120 x 46 mm, 5 μm particle size)] , using a mobile phase containing methanol: 10 mM pH 7.0 pho...
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2017
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th-cmuir.6653943832-423142017-09-28T04:26:25Z High-performance liquid chromatographic method for the analysis of fluconazole in pharmaceutical preparations Limpiti D. Lhieochaiphant D. O-ariyakul N. High-performance liquid chromatographic method was developed for the analysis of fluconazole in pharmaceutical preparations. The analyzed drug was separated on a reversed-phase column [Hypersil ODS column (120 x 46 mm, 5 μm particle size)] , using a mobile phase containing methanol: 10 mM pH 7.0 phosphate buffer (50:50) with UV detection at 260 nm. The proposed method is specific, sensitive, reproducible and reliable. It can be successfully applied as a stability-indicating method for the determination of fluconazole in pharmaceutical preparations. With a run time of less than 2 minutes, the method is rapid and easy to use for routine analysis of fluconazole in pure form and dosage form as well as for its dissolution testing. 2017-09-28T04:26:24Z 2017-09-28T04:26:24Z 2016-01-01 Journal 16851994 2-s2.0-84991061167 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991061167&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/42314 |
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High-performance liquid chromatographic method was developed for the analysis of fluconazole in pharmaceutical preparations. The analyzed drug was separated on a reversed-phase column [Hypersil ODS column (120 x 46 mm, 5 μm particle size)] , using a mobile phase containing methanol: 10 mM pH 7.0 phosphate buffer (50:50) with UV detection at 260 nm. The proposed method is specific, sensitive, reproducible and reliable. It can be successfully applied as a stability-indicating method for the determination of fluconazole in pharmaceutical preparations. With a run time of less than 2 minutes, the method is rapid and easy to use for routine analysis of fluconazole in pure form and dosage form as well as for its dissolution testing. |
| format |
Journal |
| author |
Limpiti D. Lhieochaiphant D. O-ariyakul N. |
| spellingShingle |
Limpiti D. Lhieochaiphant D. O-ariyakul N. High-performance liquid chromatographic method for the analysis of fluconazole in pharmaceutical preparations |
| author_facet |
Limpiti D. Lhieochaiphant D. O-ariyakul N. |
| author_sort |
Limpiti D. |
| title |
High-performance liquid chromatographic method for the analysis of fluconazole in pharmaceutical preparations |
| title_short |
High-performance liquid chromatographic method for the analysis of fluconazole in pharmaceutical preparations |
| title_full |
High-performance liquid chromatographic method for the analysis of fluconazole in pharmaceutical preparations |
| title_fullStr |
High-performance liquid chromatographic method for the analysis of fluconazole in pharmaceutical preparations |
| title_full_unstemmed |
High-performance liquid chromatographic method for the analysis of fluconazole in pharmaceutical preparations |
| title_sort |
high-performance liquid chromatographic method for the analysis of fluconazole in pharmaceutical preparations |
| publishDate |
2017 |
| url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991061167&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/42314 |
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