Kidney biomarkers in MCPA-induced acute kidney injury in rats: Reduced clearance enhances early biomarker performance

• Main Authors: Wunnapuk K., Liu X., Gobe G.C., Endre Z.H., Peake P.W., Grice J.E., Roberts M.S., Buckley N.A.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.ncbi.nlm.nih.gov/pubmed/24480514; http://www.scopus.com/inward/record.url?eid=2-s2.0-84893844954&partnerID=40&md5=d243beb2251222d8fd15ad4b0abfa559; http://cmuir.cmu.ac.th/handle/6653943832/4255
• Institution: Chiang Mai University

For improved early detection and assessment of severe acute kidney damage following accidental or intentional ingestion of the herbicide MCPA, we compared a panel of 14 novel kidney injury biomarkers with plasma creatinine. Male Wistar rats received four different oral doses of MCPA and plasma and u...