Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues
Semisynthesis of the known Stemona alkaloids oxystemofoline (7) and methoxystemofoline (8) has been achieved starting from (11Z)-1′,2′- didehydrostemofoline (6), which confirmed their structures and absolute configurations. The synthesis of (1′R)-hydroxystemofoline (9) helped establish this compound...
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th-cmuir.6653943832-432992017-09-28T06:53:55Z Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues Sastraruji K. Sastraruji T. Pyne S. Ung A. Jatisatienr A. Lie W. Semisynthesis of the known Stemona alkaloids oxystemofoline (7) and methoxystemofoline (8) has been achieved starting from (11Z)-1′,2′- didehydrostemofoline (6), which confirmed their structures and absolute configurations. The synthesis of (1′R)-hydroxystemofoline (9) helped establish this compound as a natural product from Stemona aphylla. (1′S)-Hydroxystemofoline (10) and a number of related analogues were also prepared. In a TLC bioautographic assay, 9 was found to be the most active acetylcholinesterase inhibitor, but it was not as active as galanthamine. © 2010 The American Chemical Society and American Society of Pharmacognosy. 2017-09-28T06:53:55Z 2017-09-28T06:53:55Z 2010-05-28 Journal 01633864 2-s2.0-77952982010 10.1021/np100137h https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77952982010&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43299 |
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Semisynthesis of the known Stemona alkaloids oxystemofoline (7) and methoxystemofoline (8) has been achieved starting from (11Z)-1′,2′- didehydrostemofoline (6), which confirmed their structures and absolute configurations. The synthesis of (1′R)-hydroxystemofoline (9) helped establish this compound as a natural product from Stemona aphylla. (1′S)-Hydroxystemofoline (10) and a number of related analogues were also prepared. In a TLC bioautographic assay, 9 was found to be the most active acetylcholinesterase inhibitor, but it was not as active as galanthamine. © 2010 The American Chemical Society and American Society of Pharmacognosy. |
| format |
Journal |
| author |
Sastraruji K. Sastraruji T. Pyne S. Ung A. Jatisatienr A. Lie W. |
| spellingShingle |
Sastraruji K. Sastraruji T. Pyne S. Ung A. Jatisatienr A. Lie W. Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues |
| author_facet |
Sastraruji K. Sastraruji T. Pyne S. Ung A. Jatisatienr A. Lie W. |
| author_sort |
Sastraruji K. |
| title |
Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues |
| title_short |
Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues |
| title_full |
Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues |
| title_fullStr |
Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues |
| title_full_unstemmed |
Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues |
| title_sort |
semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues |
| publishDate |
2017 |
| url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77952982010&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/43299 |
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