Severe developmental bone phenotype in ClC-7 deficient mice

• Main Authors: Neutzsky-Wulff A., Sims N., Supanchart C., Kornak U., Felsenberg D., Poulton I., Martin T., Karsdal M., Henriksen K.
• Format: Journal
• Published: 2017
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77955279416&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/43379
• Institution: Chiang Mai University

Bone development is dependent on the functionality of three essential cell types: chondrocytes, osteoclasts and osteoblasts. If any of these cell types is dysfunctional, a developmental bone phenotype can result. The bone disease osteopetrosis is caused by osteoclast dysfunction or impaired osteocla...