ClC-7 expression levels critically regulate bone turnover, but not gastric acid secretion

• Main Authors: C. Supanchart, L. Wartosch, C. Schlack, J. Kühnisch, D. Felsenberg, J. C. Fuhrmann, M. C. de Vernejoul, T. J. Jentsch, U. Kornak
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84886859886&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/53299
• Institution: Chiang Mai University

Mutations in the 2Cl-/1H+-exchanger ClC-7 impair osteoclast function and cause different types of osteoclast-rich osteopetrosis. However, it is unknown to what extent ClC-7 function has to be reduced to become rate-limiting for bone resorption. In osteoclasts from osteopetrosis patients expression o...