Molecular recognition of naphthoquinone-containing compounds against human DNA topoisomerase IIα ATPase domain: A molecular modeling study

• Main Authors: Panupong Mahalapbutr, Phakawat Chusuth, Nawee Kungwan, Warinthorn Chavasiri, Peter Wolschann, Thanyada Rungrotmongkol
• 格式: 雜誌
• 出版: 2018
• 主題: Chemistry; Materials Science; Agricultural and Biological Sciences; Arts and Humanities
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85031103516&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/43442
• 機構: Chiang Mai University

© 2017 Elsevier B.V. Several quinone-based metabolites of anticancer drugs and naturally occurring quinone-containing compounds have been characterized as potent inhibitors toward topoisomerase IIα (TopoIIα), an essential enzyme involved in maintaining genomic integrity during DNA replication and mi...