Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines

• Main Authors: Kanyani Sangpheak, Monika Mueller, Nitchakan Darai, Peter Wolschann, Chonticha Suwattanasophon, Ritbey Ruga, Warinthon Chavasiri, Supaporn Seetaha, Kiattawee Choowongkomon, Nawee Kungwan, Chompoonut Rungnim, Thanyada Rungrotmongkol
• Format: Journal
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056085391&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/62944
• Institution: Chiang Mai University

© 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Targeted cancer therapy has become one of the high potential cancer treatments. Human topoisomerase II (hTopoII), which catalyzes the cleavage and rejoining of double-stranded DNA, is an important...